Mechanisms of therapy resistance in osteosarcoma: a review
ثبت نشده
چکیده
Therapy resistance remains a challenge in the treatment for osteosarcoma (OS). By studying therapy resistance and gaining biological understanding of resistance in OS, novel treatment targets to sensitise OS could potentially be discovered. The aim of this review is to give an overview of the mechanisms of resistance employed by OS cells after cytotoxic treatment, the key molecules involved in therapy resistance combined with the (pre)clinical research performed on this subject in a search to discover means to overcome therapy resistance and thus improve treatment efficacy for OS.
منابع مشابه
Molecular mechanisms involved in multidrug resistance in breast cancer therapy
Breast cancer is the most prevalent cancer in women. Chemotherapy is the main strategy in the treatment of this disease especially in the advanced form of the disease. Despite the recent progress in the development of new chemotherapy, the effectiveness of these drugs has dramatically reduced due to multidrug resistance. The phenotype of multidrug resistance (MDR) can occur through different me...
متن کاملResistance to HER2-targeted therapy
Production and approval of trastuzumab (Herceptin®) for the treatment of metastatic breast cancer (MBC) was a millstone in antibody-based targeted therapy in the cancer treatment. However, despite the early success in the clinical trials, trastuzumab failed to appreciate the initial attraction due to development of resistance to the drug. The majority of patients who benefit from the drug...
متن کاملNatural and herbal compounds targeting breast cancer, a review based on cancer stem cells
Cancer stem cells (CSCs) are known as the major reason for therapy resistance. Recently, natural herbal compounds are suggested to have a significant role in inhibiting the breast cancer stem cells (BCSCs). The aim of this study was to explore the effective natural herbal compounds against BCSCs.This review article was designed based on the BCSCs, mechanisms of therapy resistance and natural he...
متن کاملReview of mechanisms and recent advances in cancer photo thermal therapy
Abstract. Cancer is a major health problem all over the world. Photo thermal therapy (PTT) is a non-invasive method in cancer treatment. In PTT, the laser light usually in near-infra red region is absorbed and converted to heat in the cancerous tissue. The temperature above 40 ° C in PTT can induce some effects including irreversible damage to proteins, changes in enzyme struc...
متن کاملAntifungal drug resistance of yeasts in dermatology: mechanisms, epidemiology and clinical impact
Superficial dermatophytoses are among the most common infectious disease. The most commonly used antifungal categories reazoles, polyenes and echinocandins. Due to the limited number of available antifungal drugs, toxicity and the emergence of resistant (intrinsic or acquired) strains, antifungal strategy needs to be developed. Recently the researchers try to find alternative antifungal agents....
متن کامل